Each tablet contains 1.9% of Afoxolaner and 0.4% of Milbemycin Oxime.
- Afoxolaner is a broad-spectrum antiparasitic used to kill external parasites such as fleas and ticks. Afoxolaner is absorbed into the bloodstream and distributed throughout the body where it is ingested by parasites as they feed. The drug works by blocking the transmission of neuronal signals, resulting in hyperexcitation, paralysis and death.
- Milbemycin Oxime is an endoparasiticide and ectoparisiticide, meaning it kills both internal and external parasites. It is effective against heartworms, intestinal worms and mites. It works by interfering with the glutamate neuro-transmission, leading to paralysis and death.
The safety of NexGard Spectra has not been established during pregnancy and lactation or in breeding dogs.