Fluralaner is an acaricide and insecticide. It is efficacious against ticks (Ixodes spp., Dermacentor spp. , and Rhipicephalus sanguineus) and fleas (Ctenocephalides spp.) on the dog. Fluralaner is systemically active on target parasites. Contact activity against ticks and fleas is of minor relevance. Fluralaner is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate-receptor). In a molecular on target study, Fluralaner is not affected by dieldrin resistance. In vitro, Fluralaner overcomes resistance against amidines, organophosphates, cyclodienes, macrocyclic lactones, phenylpyrazoles, benzophenyl ureas, pyrethroids and carbamates. In vivo, Fluralaner is highly effective against fleas proven to be less susceptible to phenylpyrazole insecticides.